PHENOTYPIC AND FUNCTIONAL-ANALYSIS OF LEUKEMIC-CELLS FROM 16 PATIENTS WITH ADULT T-CELL LEUKEMIA LYMPHOMA

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 61  (1) , 192-199
Abstract
Surface phenoytpes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM[pokeweed mitogen]-induced normal B-cell differentiation was also studied. The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a antigen, and were unreactive with MAS 036 c. ATLL cells are of peripheral inducer/helper T-cell origin. Contrary to the surface phenotype, ATLL cells from 10 patients showed potent suppressor activity on PWM-induced normal B-cell differentiation to Ig-producing cells (Ig-PC) and no case showed helper activity. The dissociation between surface phenotype and function of ATLL cells is discussed.