Effect of Stress, Adrenocorticotropin or Corticosteroid Treatment, Adrenalectomy, or Hypophysectomy on Hypothalamic Immunoreactive Adrenocorticotropin Concentrations*
- 1 September 1979
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 105 (3) , 737-742
- https://doi.org/10.1210/endo-105-3-737
Abstract
Despite variations in plasma and/or pituitary ACTH concentrations, no changes in median eminence or medial basal hypothalamic immunoreactive ACTH-like concentrations were seen in rats studied 6 weeks posthypophysectomy,12 h or 28 days after bilateral adrenalectomy, 6 days after implantation of corticosterone pellets (75 mg), after dexamethasone administration (300 μg/100 g BW, ip, twice daily for 4 days), or after chronic immobilization stress. The lack of concordant variation of brain, pituitary, and plasma ACTH concentrations further supports the suggestion of a nonpituitary, central nervous system origin of some portion of brain immunoreactive ACTH-like activity.Keywords
This publication has 21 references indexed in Scilit:
- Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.Proceedings of the National Academy of Sciences, 1977
- Common precursor to corticotropins and endorphinsProceedings of the National Academy of Sciences, 1977
- Presence of immunoassayable β-lipotropin in bovine brain and spinal cord: Lack of concordance with ACTH concentrationsBiochemical and Biophysical Research Communications, 1977
- Lipotropin: Localization by radioimmunoassay of endorphin precursor in pituitary and brainBiochemical and Biophysical Research Communications, 1977
- Presence of corticotropin in brain of normal and hypophysectomized rats.Proceedings of the National Academy of Sciences, 1977
- Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activityProceedings of the National Academy of Sciences, 1976
- Failure of hypophysectomy to alter brain content of opioid peptides (endorphins)Life Sciences, 1976
- Changes in pituitary corticotrophic function in the adrenalectomized ratThe Journal of Physiology, 1964
- Chromatography and Hormonal Activities of Dog HypothalamusEndocrinology, 1962
- On the Presence in Hog Hypothalamus of (β-Corticotropin Releasing Factor,α- and (β-Melanocyte Stimulating Hormones, Adrenocorticotropin, Lysine-Vasopressin and OxytocinEndocrinology, 1962