Coordinated Expression of Tracheal Antimicrobial Peptide and Inflammatory-Response Elements in the Lungs of Neonatal Calves with Acute Bacterial Pneumonia
Open Access
- 1 May 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (5) , 2950-2955
- https://doi.org/10.1128/iai.71.5.2950-2955.2003
Abstract
Lung tissue removed from neonatal calves with acuteMannheimia haemolyticapneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-κB, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of β-defensin and inflammatory elements occurs during bacterial pneumonia.Keywords
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