THE PROPHYLACTIC EFFECT OF DOXYCYCLINE ON POSTOPERATIVE INFECTION-RATE AFTER 1ST-TRIMESTER ABORTION

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  • 1 November 1987
    • journal article
    • research article
    • Vol. 70  (5) , 755-758
Abstract
A prospective double-blind study was performed to evaluate the effect of prophylactic antibiotic treatment before induced abortion. Eight hundred consecutive women admitted for first-trimester abortion, without signs of genital infection or antibiotic use in the last three weeks, were included in the study. Doxycycline 400 mg or placebo was given as a single oral dose ten to 12 hours before vacuum aspiration. Ninety-one women (11.8%) returned to the hospital with suspected complications. Thirty-two of these women were diagnosed as having pelvic inflammatory disease, eight of whom (2.1%) had received doxycycline before the abortion and 24 of whom (6.2%) had received placebo, a statistically significant difference (P < .01). A history of pelvic inflammatory disease increased the risk of developing it again after an abortion.

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