Studies in Hypersensitiveness

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Abstract
Summary: A quantitative study of the interaction between atopic reagin and its related atopen confirms the observation of Coca and Grove that the reagin is neutralized, that is, deprived of its sensitizing power by the admixture of the atopen, but that the activity of the latter is not lessened in any apprecible degree by the presence of its related reagin in the mixture. Confirming the observation of Coca and Grove, repeated reactions were obtained in the same sensitized site with the same concentration of the atopen. Such repeated reactions could be obtained even when the first “dose” of the atopen was mixed with the serum containing the reagin in vitro, that is, before its injection into the normal skin. The law of Coca and Kosakai regarding the fractional neutralization of precipitin applies in a modified form to the fractional “neutralization” of atopic reagin. After a passively sensitized skin site has been rendered insensitive, by repeated injections, to a certain concentration of the related atopen, a further reaction can be elicited with a stronger concentration, the ratio of the two concentrations being apparently constant with one atopic serum in the same skin.

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