MEASURING PATIENT COMPLIANCE IN ANTIHYPERTENSIVE THERAPY—SOME METHODOLOGICAL ASPECTS

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Abstract
The usefulness of prescription refilling patterns in assessing compliance was studied retrospectively in 331 subjects receiving antihypertensive drugs during 1 and 2-yr follow-up periods. The compliance distribution was J-shaped for both periods. The number of compliant patients decreased slightly when the follow-up period increased from 1 to 2 yr. An arbitrary cutoff point (0.7) yielded 34% noncompliers during the 2-yr period. By interviewing patients, an additional 5% of noncompliers, so-called early drop-outs, were identified among those who had filled no antihypertensive prescriptions during the 2-yr period. The 2nd follow-up yr yielded little additional information. Reliability of the results obtained with prescription monitoring was also assessed by interviewing patients concerning eventual hospital stays and physicians'' verbal orders that were not recorded on the prescriptions. These factors did not affect the overall compliance distribution, even though some patients might have been classified incorrectly because of them. In research settings and in daily practice, prescription monitoring is a useful tool for assessing patient compliance.