Contribution of Research in Basic and Clinical Sciences in Japan.

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Abstract
To investigate the degree of Japan's contribution in basic and clinical research in the last decade. Original articles published in 1990-2000 in highly reputed basic and clinical journals were accessed through MEDLINE database. The number of articles having affiliation with a Japanese institution was counted separately for basic and clinical journals. Of total articles, Japan's contributions in basic and clinical research were 3.1% and 0.7%, respectively (p=0.0001). The recent increase in the contribution was significant for basic research (p=0.01), but not for clinical research (p=0.91). The barriers to boosting high quality clinical research in Japan should be determined and accordingly appropriate measures should be taken forthwith.

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