Clinical Trial of a Test Stick to Control Patient Compliance under Nomifensine Treatment

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Abstract
A reliable and rapid way of assessing patient compliance is the use of a semi-quantitative drug determination in the urine. Almost all urines were positive to a microchromatographic test stick 2-6 h after 25 or 100 mg nomifensine was taken orally by healthy normal volunteers. The test reliability between different observers varied between 76-100%. False positive results were regularly observed with carbamazepine and triamterene, and false negatives or weakened reactions with Li. The test is reliable and highly time-specific. Its applicability is restricted to very specific questions.