High-Pressure Gas Chromatography and Chromatography with Supercritical Fluids. IV. Fluid-Solid Chromatography

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Abstract
A chromatographic separation process is described which uses a supercritical fluid as mobile phase in combination with a solid adsorbent. Experiments have been conducted at temperatures of 200–250°C in the pressure range of 30–50 kg/cm2 with n-pentane and isopropanol as examples of mobile fluids and alumina as the adsorbent. The new technique, which may be called “fluid-solid chromatography” (FSC), is applicable to heavy substances which are difficult or even impossible to handle by normal gas-chromatographic methods. With FSC, such substances can be eluted in a short time and yield symmetrical peaks. Other attractive features include a high degree of flexibility and rapidity. It owes its versatility to the ease with which the separation pattern can be changed by variations of phase system, pressure, and temperature. The most important features of FSC are illustrated with several examples, including the analysis of tars.

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