The Biology and Behaviour of Intracerebral Adrenal Transplants in Animals and Man
- 1 January 1993
- journal article
- review article
- Published by Walter de Gruyter GmbH in Reviews in the Neurosciences
- Vol. 4 (2) , 113-146
- https://doi.org/10.1515/revneuro.1993.4.2.113
Abstract
The catecholamine containing chromaffin cells of the adrenal medulla have recently been employed as intracerebral grafts in man and animals with lesions of the nigrostriatal dopaminergic system. This review outlines the basic biology of the chromaffin cell with reference to its efficacy as a source of dopamine in the grafted state. This is followed by an evaluation of the use of these grafts in experimentally lesioned animals and in patients with Parkinson's disease.Keywords
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