Conversion-Associated Recombination in Yeast
- 1 January 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (1) , 101-105
- https://doi.org/10.1073/pnas.69.1.101
Abstract
Gene conversion and conversion-associated reciprocal recombination have been studied in various Saccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at the arg4, thr3, his1, and SUP6 loci. Of these conversions, 445 (or 49.1%) were associated with reciprocal recombination of bracketing markers no more than 20-centimorgans apart. For conversions of two other loci, his2 and thr1, for which the bracketing markers were more than 20-centimorgans apart, recombination frequencies were significantly greater than 50%. These findings are discussed in terms of current models of genetic recombination. It is suggested that all meiotic crossing-over is characterized by the recombination events that are associated with conversion.Keywords
This publication has 5 references indexed in Scilit:
- One way to think about gene conversion.1969
- INFORMATIONAL TRANSFER IN MEIOTIC GENE CONVERSIONProceedings of the National Academy of Sciences, 1969
- Amino acid replacements resulting from super-suppression of a nonsense mutant of yeastBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1968
- A Theory of Crossing-Over by Means of Hybrid Deoxyribonucleic AcidNature, 1963
- THE RELATIONSHIP OF GENE CONVERSION TO CROSSING OVER IN NEUROSPORAProceedings of the National Academy of Sciences, 1959