A Comparison of Phospholipase Activity, Cellular Adherence and Pathogenicity of Yeasts

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Abstract
Phospholipase A and lysophospholipase activities were measured in the culture fluid and in the blastospores of Candida albicans. When phospholipase activity was measured in 6 yeasts (four strains of C. albicans and a single strain each of C. parapsilosis and Saccharomyces cerevisiae), a correlation was found between this activity and 2 potential parameters of pathogenicity. The C. albicans isolates which adhered most strongly to buccal epithelial cells and which were most pathogenic in mice had the highest phospholipase activities. Non-pathogenic yeasts, including C. albicans isolates which did not kill mice, had lower phospholipase activities.