Studies in man of phenytoin absorption and its implications.
- 1 March 1975
- journal article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 38 (3) , 219-224
- https://doi.org/10.1136/jnnp.38.3.219
Abstract
The absorption of phenytoin was studied in man. It is concluded that phenytoin absorbed from the intestine is recirculated via the bile, so that blood levels do not accurately reflect absorption. Phenytoin is loosely bound to serum proteins and is found in red cells in concentrations similar to those in plasma. It is rapidly lost from the blood stream after intravenous administration, which is an important factor to be considered in the treatment of status epilepticus.Keywords
This publication has 14 references indexed in Scilit:
- PLASMA PROTEIN BINDING, PLASMA CONCENTRATIONS, AND EFFECTS OF DIPHENYLHYDANTOIN IN MAN*Annals of the New York Academy of Sciences, 1971
- Plasma protein binding of diphenylhydantoin in man; Interaction with other drugs and the effect of temperature and plasma dilutionClinical Pharmacology & Therapeutics, 1970
- Phenytoin Tolerance TestsBMJ, 1970
- Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatographyAnalytical Chemistry, 1970
- Plasma protein binding of tricyclic anti-depressants in manBiochemical Pharmacology, 1969
- Metabolic disposition of diphenylhydantoin in normal human subiects following intravenous administrationClinical Pharmacology & Therapeutics, 1969
- Comparison of blood levels with oral and intramuscular diphenylhydantoinNeurology, 1968
- Serum Protein Binding of Thyroxine and DiphenylhydantoinJournal of Clinical Endocrinology & Metabolism, 1966
- Intramuscular administration of phenytoinNeurology, 1966
- Studies on the metabolism of diphenylhydantoin (Dilantin)Neurology, 1961