Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis
- 1 October 1989
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 83 (3) , 287-288
- https://doi.org/10.1007/bf00285174
Abstract
The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.22)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY,+der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(123.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.This publication has 7 references indexed in Scilit:
- The 11q;22q translocation: A collaborative study of 20 new cases and analysis of 110 familiesHuman Genetics, 1983
- Partial 11q trisomy syndromeHuman Genetics, 1981
- A deleted extra chromosome 22 identified by DNA replication bandingHuman Genetics, 1980
- Tertiary trisomy (22q11q),47,+der(22),t(11;22)Human Genetics, 1980
- Structural aberrations of the long arm of chromosome no. 22: Report of a family with translocation t(11;22) (q25;q11)*Clinical Genetics, 1976
- High Resolution of Human ChromosomesScience, 1976
- [2 cases of trisomy 11q(q231--qter) by translocation t(11;22) (q231;q111) in 2 different families].1975