Isoproterenol‐induced Mg2+ uptake in liver
Open Access
- 3 August 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 307 (3) , 333-336
- https://doi.org/10.1016/0014-5793(92)80707-n
Abstract
Isoproterenol increased the Mg2+ content of hepatocytes after injection into rats or after addition to collagenase‐dispersed hepatocytes. cAMP also the increased cellular Mg2+ content of isolated hepatocytes. This effect was prevented by staurosporine. Phorbol ester had no effect on the Mg2+ content of isolated hepatocytes, and after injection of isoproterenol into rats, protein kinase C of liver was not affected. It was concluded that isoproterenol induced long‐term Mg2+ influx via the activation of protein kinase A which can be inhibited by staurosporine.Keywords
This publication has 15 references indexed in Scilit:
- Activation of Na+/Mg2+antiport in thymocytes by cAMPFEBS Letters, 1992
- Regulation of Mg2+ uptake in isolated rat myocytes and hepatocytes by protein kinase CFEBS Letters, 1992
- Norepinephrine evokes a marked Mg2+ efflux from liver cellsFEBS Letters, 1990
- Characterization of Na+-dependent Mg2+ efflux from Mg2+-loaded rat erythrocytesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Effect of isoproterenol (ISO) on rat heart, liver, kidney, and muscle tissue levels of zinc, copper, and magnesiumBiological Trace Element Research, 1986
- Studies and Perspectives of Protein Kinase CScience, 1986
- Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinaseBiochemical and Biophysical Research Communications, 1986
- Measurement of protein using bicinchoninic acidAnalytical Biochemistry, 1985
- Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.Proceedings of the National Academy of Sciences, 1980
- Preparation of rat liver cellsExperimental Cell Research, 1973