Synthesis of Chiral Triamine Ligands from Ephedrine and Pseudoephedrine
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (02) , 109-110
- https://doi.org/10.1055/s-1990-21004
Abstract
Ephedrine (2) and pseudoephedrine (3) can be alkylated with α-chloro-N,N-dimethylacetamide and converted regio- and stereospecifically into 1,2-diphenyl-3,4,7-trimethyl-1,4,7-triazaoctanes 1 and 6 via a substitution reaction at the carbinol stereogenic center.Keywords
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