The case reported, while in the main one of angioneurotic edema, differs from the type commonly seen in that it embodies in its manifestations almost all the features of this disease. Its decided hereditary tendency, its appearance early in life, its persistent and frequent attacks, with pronounced local and general manifestations and a clinical course at times suggestive of an acute infection, stamp it as unusual. The possibility of confusing it with the expression of some sudden severe systemic derangement, the protean manifestation of some vascular disturbance such as acroparesthesia, or classifying it as the familial type of edema described by Edgeworth or even as Milroy's disease is not unlikely. REPORT OF CASE History. —L., a white man, aged 24, born in Missouri, where he resided until his induction into military service, entered the base hospital at Camp Dodge, July 24, 1918, with the provisional diagnosis of "edema, origin undetermined."