Drosophila ATM and Mre11 Are Essential for the G2/M Checkpoint Induced by Low-Dose Irradiation
Open Access
- 1 October 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 171 (2) , 845-847
- https://doi.org/10.1534/genetics.105.047720
Abstract
Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G2/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.Keywords
This publication has 19 references indexed in Scilit:
- Requirement of the Mre11 Complex and Exonuclease 1 for Activation of the Mec1 Signaling PathwayMolecular and Cellular Biology, 2004
- Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effectGenes & Development, 2004
- Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA ComplexesScience, 2003
- An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA ReplicationMolecular Cell, 2003
- DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1Nature Cell Biology, 2002
- Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing IrradiationMolecular and Cellular Biology, 2002
- Cell cycle checkpoint signaling through the ATM and ATR kinasesGenes & Development, 2001
- Chk2 Activation Dependence on Nbs1 after DNA DamageMolecular and Cellular Biology, 2001
- Coordination of Growth and Cell Division in the Drosophila WingCell, 1998
- The ATM gene and the radiobiology of ataxia-telangiectasiaInternational Journal of Radiation Biology, 1996