Effect of Drug Therapy of Hemorrhagic Hypotension on Kinetics of Peritoneal Dialysis in the Dog

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Abstract
Peritoneal dialysis is commonly used as an adjunct in the treatment of acute and chronic renal failure. It has been shown previously that if peritoneal dialysis is carried out during hemorrhagic hypotension there is a reduction in the peritoneal transfer rate of urea and potassium; restoration of blood volume results in a return of the efficiency of peritoneal dialysis. In this study utilizing dogs the effect of norepinephrine and phenoxybenzamine on the efficiency of peritoneal dialysis in hypotension is evaluated. During hemorrhagic hypotension, norepinephrine raises arterial pressure to control values while phenoxybenzamine causes a further fall in mean arterial pressure, but neither agent significantly changes the rate of peritoneal transfer of urea or potassium. It is concluded that the use of vasoconstrictor or vasodilator agents in hemorrhagic hypotension does not significantly influence the efficiency of peritoneal dialysis.

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