The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Top Cited Papers
Open Access
- 17 July 2003
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 17 (15) , 1841-1854
- https://doi.org/10.1101/gad.1105003
Abstract
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli including growth factor withdrawal and endogenous levels of Pim-2 contributed to growth factor-mediated apoptotic resistance. Pim-2 expression maintained cell size and mitochondrial potential independently of the PI3K/Akt/TOR pathway. Pim-2-dependent maintenance of cell size and survival correlated with its ability to maintain rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of the BH3 protein BAD. These results establish Pim-2 as a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival.Keywords
This publication has 55 references indexed in Scilit:
- Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 FunctionJournal of Biological Chemistry, 2002
- A molecular compendium of genes expressed in multiple myelomaBlood, 2002
- Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient UptakeMolecular Biology of the Cell, 2002
- Translational Control of Cell Fate: Availability of Phosphorylation Sites on Translational Repressor 4E-BP1 Governs Its Proapoptotic PotencyMolecular and Cellular Biology, 2002
- Genes Preferentially Induced by Depolarization after Concussive Brain Injury: Effects of Age and Injury SeverityJournal of Neurotrauma, 2002
- Spotting prostate cancerTrends in Molecular Medicine, 2001
- Delineation of prognostic biomarkers in prostate cancerNature, 2001
- Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell TransitionJournal of Biological Chemistry, 2001
- Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-mycOncogene, 1997
- Complementation tagging of cooperating oncogenes in knockout miceSeminars in Cancer Biology, 1996