Mast Cells in the Skin: Progressive Systemic Sclerosis and the Toxic Oil Syndrome

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Abstract
To the editor: Hawkins and coworkers (1) showed a specific increase in the number of mast cells in clinically affected skin of patients with the early indurative stage of progressive systemic sclerosis. We have studied mast cells in the skin of patients with different stages of the toxic oil syndrome. This syndrome, which has a marked similarity to progressive systemic sclerosis, appeared as an epidemic in Spain in 1981. Some 22 000 persons were affected by this syndrome, having acute fever, cough, blood, eosinophilia, cutaneous exanthema, pruritus, myalgia, arthralgia, headache, noncardiogenic pulmonary edema, and gastrointestinal symptoms. From the second month

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