Dominant Negative Regulation of the Mouse α-Fetoprotein Gene in Adult Liver
- 21 December 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 250 (4988) , 1732-1735
- https://doi.org/10.1126/science.1702902
Abstract
Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.Keywords
This publication has 29 references indexed in Scilit:
- The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract.The Journal of cell biology, 1990
- αβ lineage-specific expression of the α T cell receptor gene by nearby silencersCell, 1989
- Postnatal repression of the alpha-fetoprotein gene is enhancer independent.Genes & Development, 1989
- Two Mechanisms for the Extinction of Gene Expression in Hybrid CellsScience, 1988
- Raf , a Trans -Acting Locus, Regulates the α-Fetoprotein Gene in a Cell-Autonomous MannerScience, 1987
- Diversity of Alpha-Fetoprotein Gene Expression in Mice Is Generated by a Combination of Separate Enhancer ElementsScience, 1987
- Identification of sites required for repression of a silent mating type locus in yeastJournal of Molecular Biology, 1984
- Regulation of mating-type information in yeastJournal of Molecular Biology, 1984
- Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNAEuropean Journal of Biochemistry, 1980
- Genetic control of alpha-fetoprotein synthesis in the mouse.The Journal of Experimental Medicine, 1977