CELL-POPULATION SIZE DEPENDENCY OF THERAPEUTIC EFFECT OF DIVIDED DOSAGE OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE
- 1 January 1976
- journal article
- research article
- Vol. 67 (3) , 461-464
Abstract
A total dose of 960 mg/kg body weight of 1-.beta.-D-arabinofuranosylcytosine (cytosine arabinoside) was given i.p. to rats bearing Yoshida sarcoma, in single or divided doses. Single dose therapy gave an increased life span of about 1 day irrespective of cell population size in accord with the concept of constant percentage cell kill. Tumor cell reduction was estimated to be about 70%. Divided dose therapy induced increased life span which was reciprocally proportional to the logarithm of population size. Estimated cell reduction was 87% when population size was 108 cells and 99.95% at 104 cells.This publication has 3 references indexed in Scilit:
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