Acetylcysteine and Nephrotoxic Effects of Radiographic Contrast Agents — A New Use for an Old Drug

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Abstract
Nephrotoxicity of radiographic contrast agents is an important cause of acute renal failure even when measures are taken to reduce these toxic effects. Such toxic effects prolong hospital stays, add to the cost of medical care, and can be fatal. The incidence of radiographic-contrast-agent–induced acute renal failure, currently estimated to be as high as 50 percent among patients with diabetes mellitus and preexisting renal disease who receive contrast agents, is likely to remain high as the use of invasive radiologic procedures to diagnose and treat complex disease continues to grow.Prevention or mitigation of renal failure after the administration of . . .