An enhancer responsible for activating transcription at the midblastula transition in Xenopus development.
Open Access
- 1 April 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (8) , 2331-2335
- https://doi.org/10.1073/pnas.84.8.2331
Abstract
Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-beta-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.Keywords
This publication has 38 references indexed in Scilit:
- Trans-acting nuclear protein responsible for induction of rearranged human immunoglobulin heavy chain geneCell, 1986
- A 46-nucleotide promoter segment from an IFN-α gene renders an unrelated promoter inducible by virusCell, 1985
- Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevisCell, 1984
- Enhancer-like properties of the 60/81 bp elements in the ribosomal gene spacer of Xenopus laevisCell, 1984
- Specific interaction between enhancer-containing molecules and cellular componentsCell, 1984
- A major developmental transition in early xenopus embryos: II. control of the onset of transcriptionCell, 1982
- A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stageCell, 1982
- Expression of a β-globin gene is enhanced by remote SV40 DNA sequencesPublished by Elsevier ,1981
- Internal organization of the major adult α- and β-globin genes of X. laevisCell, 1980
- RNA synthesis during the development of Xenopus laevis, the South African clawed toadJournal of Molecular Biology, 1964