ANTI-TUMOR ACTIVITY OF 7-N-(PARA-HYDROXYPHENYL)-MITOMYCIN-C IN EXPERIMENTAL TUMOR SYSTEMS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 72  (6) , 944-949
Abstract
The antitumor activity of 7-N-(p-hydroxyphenyl)-mitomycin C (M-83) was compared with that of mitomycin C (MMC) in rodent tumor systems. M-83 exhibited more potent activity than MMC against the ascitic form of [mouse] lymphocytic leukemia P388 and [mouse] fibrosarcoma Meth 1; doses of over 5 mg/kg of M-83 (1/6 LD50) resulted in some 60-day survivors. The chemotherapeutic ratio (optimal dose/ED50) of M-83 was .apprx. 64 and was estimated to be .apprx. 5-8 times higher than that of MMC. Upon i.v. administration, M-83 also gave a better survival and showed a higher chemotherapeutic ratio than MMC against i.v. implanted P388. M-83 inhibited the growth of solid form of [mouse] sarcoma 180 to the same extent as MMC at an equivalent dose, but showed a higher safety margin than MMC. M-83 was as effective as MMC against [mouse] Lewis lung carcinoma at dose levels giving the same degree of toxicity. In vitro studies on tumor growth inhibition demonstrated that the cytotoxic effects of M-83 against leukemia P388 and fibrosarcoma Meth 1 cells were similar to and stronger than those of MMC, respectively.

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