Autoregulation of total and local renal blood flow in the rat during acute unilateral ureteral pressure elevation

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Abstract
The rat kidney autoregulates its blood flow (RBF) when renal arterial blood pressure (RAP) is lowered, but less efficiently than does the dog kidney. We wanted to investigate to what extent acute unilateral elevation of ureteral pressure (UP) in the Sprague‐Dawley rat would interfere with the renal vasodilatory responses elicited by RAP reduction and by intraarterial infusion of acetylcholine (Ach). RBF was significantly better autoregulated before than during UP elevation to 43 mmHg (pp125I‐iodoantipyrine, was studied in a second group of rats at an UP averaging 32 mmHg. Fractional zonal blood flow decreased in outer third (pp<0.05). This redistribution was not detected if cortex was divided in halves only.