Nature and Significance of Concentration Relations of Potassium and Sodium Ions in Skeletal Muscle

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Abstract
The basic principles underlying the concentration of K in skeletal muscle fibers and the regulation of the Na ion concentration therein are discussed. Volume and composition of fiber H2O and intrafiber composition, isosmolar relation between fibers and plasma, ionic permeability of skeletal muscle fiber, the theory of K accumulation in muscle, distribution of muscle Na, excretion of sodium ions from skeletal muscle, and the biological significance of K accumulation in cells are included in study.