WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects
Top Cited Papers
- 16 November 2005
- journal article
- review article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 32 (10) , 647-674
- https://doi.org/10.1111/j.0303-6987.2005.00495.x
Abstract
The new WHO/EORTC classification for cutaneous lymphomas comprises mature T‐cell and natural killer (NK)‐cell neoplasms, mature B‐cell neoplasms, and immature hematopoietic malignancies. It reflects the unique features of lymphoproliferative diseases of the skin, and at the same time it is as compatible as possible with the concepts underlying the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in this new classification. These findings always have to be interpreted in the context of the clinical features and biologic behavior. Aim: To review the histological, phenotypical and molecular genetic features of the various nosological entities of the new WHO/EORTC classification for cutaneous lymphomas. Methods: Extensive review of the literature cited in Medline and own data of the authors. Results: The WHO/EORTC classification of cutaneous lymphomas comprises mature T‐cell and NK‐cell neoplasms, mature B‐cell neoplasms and immature hematopoietic malignancies. It reflects the unique features of primary cutaneous lymphoproliferative diseases. Conclusion: This classification is as much as possible compatible with the concept of the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. The histological, phenotypical and molecular genetic features always have to be interpreted in the context of the clinical features and biologic behavior.Keywords
This publication has 181 references indexed in Scilit:
- Mycosis fungoides with a CD56+ immunophenotypeJournal of the American Academy of Dermatology, 2005
- Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-γ (MIG) gene expression in B-cell malignancyLeukemia, 2005
- Molecular cytogenetic characterization of Sézary syndromeGenes, Chromosomes and Cancer, 2003
- Detection of circulating T cells with CD4+CD7− immunophenotype in patients with benign and malignant lymphoproliferative dermatosesJournal of the American Academy of Dermatology, 1996
- bcl-2 Protein Expression and Correlation with the Interchromosomal 14;18 Translocation in Cutaneous Lymphomas and PseudolymphomasJournal of Investigative Dermatology, 1994
- Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders: A proposal for classification and guidelines for management and treatmentJournal of the American Academy of Dermatology, 1993
- Vesicular cutaneous T cell lymphoma presenting with gangreneJournal of the American Academy of Dermatology, 1990
- Cutaneous T cell lymphoma with suppressor/cytotoxic (CD8) phenotype: Identification of rapidly progressive and chronic subtypesJournal of the American Academy of Dermatology, 1990
- Reticulohistiocytoma of the dorsumJournal of the American Academy of Dermatology, 1988
- Histopathologic studies in Sézary syndrome and erythrodermic mycosis fungoides: A comparison with benign forms of erythrodermaPublished by Elsevier ,1986