RESULTS OF PROLONGED IRRADIATION FOR MALIGNANT CONDITIONS OF PELVIS

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Abstract
In a previous communication1I directed attention to early and late effects of radiation in the rectum and bladder following radium and roentgen irradiation for carcinoma of the cervix. Attention was directed to the importance of differentiating between late reactions and recurring malignant lesions, because further irradiation of the benign condition may cause further insult to the tissue and result in irreparable damage, such as fistulas in the bladder or rectum. The present study directs attention to a rather new clinical entity2that may develop and call for surgical intervention many months or years after complete regression or cure of the cervical cancer. In a series of 520 patients with cervical carcinomas having received radiation therapy at the Cleveland Clinic, there have been seven known cases of benign stricture of the intestine causing obstruction that might easily have been construed as, or confused with, metastatic carcinoma. In five

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