Predictive value of fibrinolytic factors in coronary heart disease
- 1 January 1999
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 59 (sup230) , 23-31
- https://doi.org/10.1080/00365519909168323
Abstract
An impaired fibrinolytic function, as evidenced by increased plasma concentrations of PAI-1, tPA antigen and tPA/PAI-1 complex, or a decreased capacity to release active tPA on exercise, is more common in individuals suffering from myocardial infarction. These factors, especially the tPA/PA-1 complex, also predict myocardial infarction in patients with manifest coronary heart disease, such as angina pectoris or a previous myocardial infarction. There is a highly statistically significant correlation between tPA/PAI-1 complex and both PAI-1 and tPA antigen. It is important to test these factors in prospective studies on healthy individuals.Keywords
This publication has 50 references indexed in Scilit:
- Tissue plasminogen activator (tPA) antigen in plasma: correlation with different tPA/inhibitor complexesScandinavian Journal of Clinical and Laboratory Investigation, 1998
- Plasminogen activator inhibitor 1 in thrombotic diseaseCurrent Opinion in Hematology, 1996
- Impaired fibrinolysis and risk of thromboembolismProgress in Cardiovascular Diseases, 1991
- Thrombosis after hip replacement: Relationship to the fibrinolytic systemActa Orthopaedica, 1989
- The organization of the human‐plasminogen‐activator‐inhibitor‐1 geneEuropean Journal of Biochemistry, 1988
- Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden cardiac death and strokeThe American Journal of Cardiology, 1988
- Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of intronsBiochemistry, 1987
- Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial InfarctionNew England Journal of Medicine, 1985
- Purification and identification of two structural variants of porcine tissue plasminogen activator by affinity adsorption on fibrinBiochimica et Biophysica Acta (BBA) - General Subjects, 1982
- Studies on the kinetics of plasminogen activation by tissue plasminogen activatorBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982