THE EFFECT OF PREVENTING ACAPNIA ON ADRENAL CORTICAL HYPERTROPHY UNDER CONDITIONS OF DECREASED BAROMETRIC PRESSURE

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Abstract
A group of albino [male] rats subjected to 280 mm. Hg in the presence of 15% CO2 and 18% O2 for 7.5 hrs./day for 5 days did not develop adrenal hypertrophy, whereas a similar group subjected to 300 mm. Hg for the same length of time in the presence of air showed a 29% hypertrophy. Evidence is given which tends to show that the presence of CO2 did not act by offsetting the anoxia but rather by preventing a disturbance in the acid-base balance. It is suggested that the adrenal cortex is stimulated by either a relative or absolute increase in basic cations or acidic anions. In the former case the adrenal cortex secretes a hormone increasing the excretion of Na in the urine and in the latter case a hormone preventing the excretion of Na in the urine.

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