Variations in Hepatic Microsomal Drug Metabolism in C57B1/6 Mice from Three Different Suppliers

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Abstract
Drug metabolism by hepatic microsomal and soluble fractions was compared in male C57B1/6 mice purchased from three different suppliers. Mice were studied at 9 weeks of age after having been purchased either as weanlings or at 8 weeks of age. Significant differences were found in the specific activity of several mixed-function oxidase enzymes and in amounts of cytochrome P-450 among the three sources of mice.