RELATIONSHIP OF CYTOPLASMIC AND NUCLEAR ESTROGEN-RECEPTORS AND PROGESTERONE RECEPTORS IN HUMAN-BREAST CANCER

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (12) , 4821-4825
Abstract
The qualitative and quantitative relationships between cytoplasmic estrogen receptors (ERC), total nuclear estrogen receptors (ERN) and cytoplasmic progesterone receptors (PGR) in 74 primary and 23 metastatic human breast cancer tissues were studied. A positive correlation between the age of the patients and the receptor concentration was found only for ERC. Although ERN and PGR were more frequent in tumors with a higher level of ERC, there was no significant correlation between concentrations of ERN or PGR and ERC. PGR were more frequent in ERN-positive than in ERN-negative tumors, irrespective of the presence of ERC. There was also a highly significant correlation between PGR and ERN concentrations. The assumption that induction of PGR by estrogen in human breast cancer is mediated by a mechanism involving nuclear receptors is supported. The ERN assay might increase the validity of steroid receptor determination for prediction of the sensitivity of human breast cancer to hormonal therapy.