INTRACAROTID BCNU (NSC-409962) - TOXICITY STUDY IN 6 RHESUS-MONKEYS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 60  (5) , 541-545
Abstract
Intracarotid artery (ica) BCNU [1,3-bis-(2-chloroethyl)-1-nitrosourea] was given at doses of 1-20 mg/kg per week for 4 wk in 6 rhesus monkeys. Vascular, neurologic and ophthalmic toxic effects were minor. The monkey receiving a dose of 15 mg/kg had transient left hemiparesis and slowing in her electroencephalogram which cleared 1 wk after the 3rd ica infusion of BCNU. At autopsy no vascular, neural or ophthalmic lesions were found. At doses of 20 mg/kg for 2 injections, 1 monkey developed fatty metamorphosis of the liver and Alzheimer II glia in the brain, yet did not develop arteriolitis, corneal damage or neurologic deficit. Reasonable doses of BCNU (less than the systemic maximum tolerated dose) should be well tolerated by ica administration in man for brain tumor treatment.

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