The Correlation of the Protective Value with the Titers of Other Antibodies in Type I Antipneumococcus Serum

Open Access
Publisher Website
Google Scholar
Abstract
Summary and Conclusions: Thirty-nine freshly drawn polyvalent type I and type II anti-pneumococcus horse sera were studied to find the degree of correlation between the protective titer and various immunological reactions, namely, specific precipitation, agglutination, neutralization, and immune protein precipitable by soluble carbohydrate. It has been found that for type I the correlation coefficient between protection and precipitin titer is 0.93; between protection and agglutination is 0.80; between protection and neutralization is 0.88; and between protection and the amount of protein precipitated with specific carbohydrate is 0.91. From this degree of correlation it appears evident that, at least for type I freshly drawn sera, immunological examination other than the expensive mouse protection test can be utilized to estimate the probable therapeutic activity and to standardize antipneumococcus serum. Reproducible and accurate results in our experience have been possible by the use of the amount of protein in the sera precipitable with the soluble specific carbohydrate.

This publication has 0 references indexed in Scilit: