Abstract
Histological changes in a case of encephalitis periaxialis concentrica of the Balo type were described. The destruction of the medullary sheaths in the concentric foci is relatively greater than that of the axones. Proliferation of the neuroglia (compound fat granule cells and large astrocytes) is associated with the destruction of the medullary sheaths. Marked perivascular infiltration with lymphocytes, plasma cells and some compound fat granule cells was noted in the concentric demyelinated foci.

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