Thyroid Function and Muscle Glycolysis in Swine

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Abstract
Three groups of cross-bred swine were utilized to examine the relationship of thyroid activity and muscle metabolism. Group I (hypothyroid) animals were surgically thyroidectomized; group II (euthyroid) were sham-operated controls; and group III (hyperthyroid) were sham-operated plus thyroxine supplemented (50 ug/kg/day). At slaughter, muscle samples were taken at exsanguination and at 60 min post-mortem. Average initial live weight was not different among treatment groups, but the controls gained significantly faster than the hypothyroid or hyperthyroid groups. At slaughter, the rate of post-mortem muscle pH decline was significantly faster among the thyroxine supplemented animals when compared to the thyroidectomized pigs. Muscle G-6-P, creatine phosphate (CP) and lactate levels at death, and G-6-P and CP levels at 60 min post-mortem were not significantly different among the treatment groups. ATP levels were significantly lower among the hyperthyroid pigs at death when compared to those of the control group. Thyroidectomy significantly retarded lactate accumulation by 1 hr post-mortem. Earlier hypotheses suggesting that PSE-prone pigs were hypothyroid appear to be invalid based on the slower accumulation of lactate among the thyroidectomized pigs and on the lower levels of ATP at death among the thyroxine-supplemented animals.

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