ROLE OF SUPPRESSOR CELLS IN ANTIBODY-INDUCED INHIBITION OF MIXED LYMPHOCYTE REACTIONS
- 1 January 1976
- journal article
- research article
- Vol. C127 (5) , 775-786
Abstract
Facilitating immune sera (FIS) have in vivo enhancing and in vitro blocking properties. They inhibit the mixed lymphocyte reaction (MLR) in the mouse. In the present report, the inhibitory capacity of these sera was studied after removal of populations of suppressor cells in vivo by adult thymectomy and in vitro by depletion of histamine-receptor-bearing cells (HRC). A significant decrease of the MLR inhibition by FIS after either of these depletions was observed. Facilitating antibodies and thymus-dependent and/or HRC apparently cooperate in the antibody-induced inhibition of the MLR in the mouse.This publication has 6 references indexed in Scilit:
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