Analogs of 8-azaguanosine
- 1 October 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (10) , 1186-1191
- https://doi.org/10.1021/jm00232a004
Abstract
Two routes for the synthesis of 6-substituted 8-azaguanosine analogs are described. Several of the compounds were tested for antineoplastic activity in [human oral carcinoma] HEp-2 cell culture and L1210 mouse leukemia systems. Only 1 compound showed high cytotoxicity and borderline L1210 activity, resulting from enzymatic conversion to 8-azaguanosine.This publication has 5 references indexed in Scilit:
- Synthesis of N10-methyl-4-thiofolic acid and related compoundsJournal of Medicinal Chemistry, 1975
- Activity of adenos1ne analogs against a cell culture, line resistant to 2-fluoroadenineBiochemical Pharmacology, 1966
- Studies on Synthetic Nucleosides V. Anomeric Pyrimidine Nucleosides of D-Arabinose and D-LyxoseCHEMICAL & PHARMACEUTICAL BULLETIN, 1965
- EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS .9. RIBONUCLEOSIDES AND RIBONUCLEOTIDES OF 2 PURINE ANTAGONISTS1962
- Purine Metabolism in Tetrahymena and Its Relation to Malignant Cells in MiceScience, 1949