Neuropathological features of a lupus‐like disorder in autoimmune mice
- 1 September 1983
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 14 (3) , 325-332
- https://doi.org/10.1002/ana.410140311
Abstract
Neurological syndromes are prominent in systemic lupus erythematosus, but the neuropathological mechanisms resulting in neurological dysfunction are unknown. We report a neuropathological study of the central nervous system in female NZB/W F1 mice, an animal model of systemic lupus erythematosus. NZB/W mice were studied at 3, 5, 8, 12, and 14 months of age, and 36-month-old female C57B16N/NIA mice were studied as aged controls. A lymphoproliferative process was identified in the central nervous system of 39% of 8- to 12-month-old and all 14-month-old NZB/W mice. Infiltrates of lymphocytes and plasma cells were seen in subarachnoid, choroid plexus interstitial, and Virchow-Robin spaces. Lymphoid cells occasionally infiltrated brain parenchyma or accumulated as nodular masses. Concomitant visceral lymphoid infiltration was noted in 14-month-old mice. Dense deposits were seen ultrastructurally in the basal lamina of brain parenchymal capillaries of 14-month-old NZB/W mice. These dense deposits were similar in appearance to immune complexes described in glomerular basal lamina, and appeared concomitantly with an advanced lupus-like glomerulopathy. Similar deposits were not observed in choroid plexus. The possible relevance of these neuropathological changes to human central nervous system lupus is discussed.This publication has 41 references indexed in Scilit:
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