Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.
- 1 September 1987
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (9) , 532-534
- https://doi.org/10.1136/jmg.24.9.532
Abstract
Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located in chromosome 8. Linkages to the thyroglobulin locus, located at 8q24, was excluded (lod < -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.This publication has 9 references indexed in Scilit:
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