The Significance of Cholesterol in the Pathogenesis of Vascular Lesions

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Abstract
IT SEEMS appropriate to recapitulate briefly our present knowledge of cholesterol metabolism before we discuss a possible connection of cholesterol with vascular disease.Cholesterol is supplied for the organism by food (exogenous quota) and by synthesis in the body itself (endogenous quota).SynthesisWe know from the experiments of Bloch1 that cholesterol is synthesized in the organism from metabolites of low-carbon chains, especially from acetic acid. Acetic acid may be derived not only from fat but also from carbohydrate and protein disintegration. It is evident, therefore, that the synthesis of cholesterol cannot be prevented by restriction of any kind of . . .

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