MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules

Open Access

22 January 2003

journal article
research article
Published by Oxford University Press (OUP) in Bioinformatics

Vol. 19 (2) , 309-310
https://doi.org/10.1093/bioinformatics/19.2.309

Abstract

Summary: Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint. Availability: Freely accessible from http://surya.bic.nus.edu.sg/mpid. Contact: shoba@bic.nus.edu.sg * To whom correspondence should be addressed.

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