UROLITHIASIS AND HYPEROXALURIA IN CHRONIC INFLAMMATORY BOWEL-DISEASE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 14  (4) , 475-479
Abstract
The incidence of urolithiasis was registered in 87 patients with chronic inflammatory bowel disease and compared with that of renal oxalate excretion. All patients were studied while on a standardized diet with fixed amounts of fat, Ca and oxalate. Pyelography had been performed in all. Nine, or 35% of 26 hyperoxaluric patients had urolithiasis, compared with 14, or 23%, of 61 patients with normal renal oxalate excretion, the difference being statistically insignificant. No significant difference in urinary oxalate or urinary Ca in stone-formers as compared with non-stone-formers was demonstrated. Oxalate was a more frequent component of calculi in patients with normal renal oxalate excretion than in patients with hyperoxaluria. No increased incidence of urolithiasis in patients with hyperoxaluria was seen compared with a control group with normal renal oxalate excretion. Enteric hyperoxaluria per se may not be the cause of stone diathesis in chronic inflammatory bowel disease.