Transforming Growth Factor-β Inhibits Lactogenic Hormone Induction of β-Casein Expression in HC11 Mouse Mammary Epithelial Cells

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Abstract
HC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms of β-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-β (TGF-β) can inhibit β-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-β also inhibits DNA synthesis of HC11 cells. These findings suggest a possible role of TGF-β as an inhibitor of functional differentiation in the mammary gland.