Turnover of lactic acid in normal and diabetic dogs calculated by two tracer methods

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Abstract
The over -all rate of production of lactate was calculated in normal and depan-creatized dogs by 2 tracer methods based either on the injection or on the primed infusion of L-(+)Lactate-14C. Slightly increased rates of production of lactate were found in diabetic animals; however, the difference was found to be significant only when the method or tracer injection was used. The rates of production calculated by the tracer injection method were significantly higher than those calculated by the tracer infusion method in both diabetic and normal dogs. Errors arising from the calculation of the rates of production of substances undergoing a very rapid turnover in the plasma from the terminal exponential component of the specific activity vs. time curve are discussed, and this method is rejected as a valid method for the study of lactate turnover in dogs.

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