ACUTE AND CHRONIC CISPLATIN NEPHROPATHY IN RATS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 44  (5) , 397-402
Abstract
Cisplatin (cis-dichlorodiammineplatinum II) is a new class of Pl coordination compounds showing a potent antitumor activity; it also produces adverse effects on renal function. Cisplatin nephropathy and renal accumulation of Pt were analyzed in rats after acute chronic treatment. A single i.p. dose of cisplatin (6 mg/kg) induced marked focal necrosis in the proximal and distal tubules with a maximum lesion on day 7. The tubular damage was localized mainly in the corticomedullary region, where the concentration of Pt was the highest within the kidney. Repeated treatment with cisplatin (1 mg/kg, i.p., twice weekly) for 11 wk resulted in massive tubular dilation in the corticomedullary region, interstitial fibrosis and thickening of tubular basement membranes. Some glomeruli appeared fibrotic, indicating that chronic treatment with cisplastin could cause irreversible renal damage. The toxicity of platinum apparently was a major factor for cisplatin nephropathy.

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