COMPARATIVE-STUDY OF THE ACTION OF LOCAL-ANESTHETICS ON AV CONDUCTIVITY OF DOG HEART INSITU

  • 1 January 1981
    • journal article
    • research article
    • Vol. 251  (2) , 285-300
Abstract
Effects of local anesthetics (procaine, lidocaine, prilocaine, mepivacaine and bupivacaine) on AV [atrioventricular] conductivity were studied using a direct perfusion technique of the canine AV node artery in situ. The agents induced dose-dependent depression of AV conductivity in doses between 100 .mu.g and 3 mg. The depression was assumed to be due to their direct action on the AV node, as it was not affected by prior administration of atropine or tetrodotoxin into the AV node artery. The order of potency to suppress AV nodal conductivity evaluated from ED50 for causing 1st-3rd degrees of AV block was bupivacaine > mepivacaine = prilocaine = lidocaine > procaine with a relative potency ratio of 5:2-2.5:1.

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