Growth pattern in boys with fragile X

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Abstract
The impression that a proportion of boys with fra(X) may show overgrowth in early infancy was investigated in a small series of 7 boys born after 1970. The fra(X) positive boys had been referred for mental retardation, or were identified in investigations of familial mental retardation. The mean birth weight was increased, and average linear growth was consistently above the mean for Danish boys with the greatest increase in the second year of life. In contrast, the weight measurements were on average below the mean until age 2 years. It is suggested that in fra(X) patients there is a disturbance of early infantile growth.